Traditionally, chemokine immunobiology has focused on chemotaxis and the positioning of
cells at sites of inflammation and within lymphoid organs. More recently, however, regulation
of intricate immune responses has emerged as a function attributed to chemokines and their
receptors. One such pair, CCR6 and its chemokine ligand CCL20, has been receiving
interest for its potential role in the coordination and regulation of humoral immune responses
and in particular, memory responses, at the cellular level. B cells up-regulate CCR6 after …