The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development

M Castellano-Pozo, T García-Muse, A Aguilera - PLoS One, 2012 - journals.plos.org
… Using Caenorhabditis elegans as a model system we show that the THO complex is essential
for mitotic genome integrity and the developmentally regulated mitotic cell cycles occurring …

[PDF][PDF] The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and

M Castellano-Pozo, T Garcıa-Muse, A Aguilera - 2012 - academia.edu
… relevance of THO during development and in adult organisms. Using Caenorhabditis elegans
as a model system we show that the THO complex is essential for mitotic genome integrity …

THO complex deficiency impairs DNA double-strand break repair via the RNA surveillance kinase SMG-1

JA Kamp, BBLG Lemmens, RJ Romeijn… - Nucleic Acids …, 2022 - academic.oup.com
… , the cell cycle stage, and the developmental context. For metazoan … To verify if the THO
complex is needed for efficient repair of DSBs … The genetics of caenorhabditis elegans

R‐loops cause replication impairment and genome instability during meiosis

M Castellano‐Pozo, T García‐Muse, A Aguilera - EMBO reports, 2012 - embopress.org
… during mitosis, but no information exists for meiosis. We used Saccharomyces cerevisiae and
Caenorhabditis elegans THO … R‐loops in the meiotic cell cycle, we used both yeast and C. …

THSC/TREX-2 deficiency causes replication stress and genome instability in Caenorhabditis elegans

A Zheleva, LP Camino… - Journal of Cell …, 2021 - journals.biologists.com
complex in development and meiosis and demonstrated that … organisms, we have analyzed
mitosis and meiosis in C. … The THO complex is recruited to chromatin and is required early …

Correction: The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development

M Castellano-Pozo, T García-Muse, A Aguilera - Plos one, 2016 - journals.plos.org
Correction: The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell
Cycle and Development … Correction: The Caenorhabditis elegans THO Complex Is …

Mechanisms of germ cell survival and plasticity in Caenorhabditis elegans

W Cao, R Pocock - Biochemical Society Transactions, 2022 - portlandpress.com
… induce cellular and molecular changes to the mitotic cell cycle and meiotic cell fate in the C.
… that pre-mRNA splicing is continuously required for germ cell development throughout the C. …

Synthetic Lethal Genetic Interactions That Decrease Somatic Cell Proliferation in Caenorhabditis elegans Identify the Alternative RFCCTF18 as a Candidate Cancer …

J McLellan, N O'Neil, S Tarailo, J Stoepel… - … biology of the cell, 2009 - Am Soc Cell Biol
elegans test system developed in this work takes advantage of the fact that cell division
defects in the vulval cell … Three vulval precursor cells (VPCs) go through three mitotic cycles to …

Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability

P Zeller, J Padeken, R van Schendel, V Kalck… - Nature …, 2016 - nature.com
… was not essential for chromosome segregation in C. … tracked the frequency of mitotic
chromosome bridges or lagging … high rates during somatic cell division in H3K9me-deficient …

Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development

A Zheleva, E Gómez-Orte, B Sáenz-Narciso… - PLoS …, 2019 - journals.plos.org
… This complex is needed for transcription elongation, mRNA export and … complex hindering
entry into mitosis. To understand how loss of function of nxf-1 disrupts the mitotic cell cycle, we …