This study provides an up-to-date and comprehensive review of the Early Palaeozoic evolution of the Brabant Massif belonging to the Anglo-Brabant Deformation Belt. Situated at the southeastern side of Avalonia microplate, it is the only well-known part of the northern passive margin of the Rheic Ocean. The Cambrian–Silurian sedimentary pile is >13km thick, with >9km for the Cambrian only. The unraveling of this continuous registration reflects the successive rifting and drifting of Avalonia from the Gondwana mainland, followed by soft-collisional processes with Baltica and finally the formation of Laurussia. Based on recently established detailed stratigraphy, sedimentology and basin development, on U–Pb LA-ICP-MS analyses of igneous and detrital zircon grains along with geochemical data including Sm–Nd isotopes, a new geodynamic and palaeogeographic evolution is proposed. Brabant Megasequence 1 (lower Cambrian to lowermost Ordovician, >9km thick) represents an embayment of the peri-Gondwanan rift from which the Rheic Ocean has evolved. Detrital zircon ages demonstrate that the Brabant is a typical peri-Gondwanan terrane with a major Pan-African (Neoproterozoic age) and a mixed West African and Amazonian source (Palaeoproterozoic, Archaean and some Mesoproterozoic age). The transition towards the Avalonia drifting is marked by an unconformity and a short volcanic episode. The northward drift of Avalonia towards Baltica is recorded by the Megasequence 2 (Middle to Upper Ordovician, 1.3km thick). The source for Mesoproterozoic zircons vanished, as the result of the Rheic Ocean opening and the isolation from Amazonian sources. The transition to Megasequence 3 is marked by a drastic change in palaeobathymetry and an important (sub)volcanic episode during a tectonic instability period (460–430Ma), reflecting the Avalonia–Baltica soft docking as also shown by the reappearance of Mesoproterozoic detrital zircons, typical of Baltica. Unradiogenic Nd isotope signature (ε_Nd −4/−5) and T_DM model ages (1.3–1.7Ga) for Brabant magmatic rocks indicate an old recycled component. Megasequence 3 (uppermost Ordovician to lowermost Devonian; >3.5km thick) includes the onset of a Silurian foreland basin that reflects the tectonic inversion of the core of the massif (Brabantian orogeny) in response to the Baltica–Avalonia–Laurentia collision. Finally, the comparison with the strikingly similar Cambrian successions of the Harlech Dome (Wales, Avalonia) and the Meguma terrane (Nova Scotia, peri-Gondwana) allows the construction of a new Early Cambrian palaeogeographic model for the whole Avalonia microplate, in which the Meguma terrane is included.