The E3 ubiquitin ligase SCF (Cyclin F) transmits AKT signaling to the cell-cycle machinery
The oncogenic AKT kinase is a key regulator of apoptosis, cell growth, and cell-cycle
progression. Despite its important role in proliferation, it remains largely unknown how AKT
is mechanistically linked to the cell cycle. We show here that cyclin F, a substrate receptor F-
box protein for the SCF (Skp1/Cul1/F-box) family of E3 ubiquitin ligases, is a bona fide AKT
substrate. Cyclin F expression oscillates throughout the cell cycle, a rare feature among the
69 human F-box proteins, and all of its known substrates are involved in proliferation. AKT …
progression. Despite its important role in proliferation, it remains largely unknown how AKT
is mechanistically linked to the cell cycle. We show here that cyclin F, a substrate receptor F-
box protein for the SCF (Skp1/Cul1/F-box) family of E3 ubiquitin ligases, is a bona fide AKT
substrate. Cyclin F expression oscillates throughout the cell cycle, a rare feature among the
69 human F-box proteins, and all of its known substrates are involved in proliferation. AKT …
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