Metastatic disease is the major cause of breast cancer–related death and despite many
advances, current therapies are rarely curative. Tumor cell migration and invasion require
actin cytoskeletal reorganization to endow cells with capacity to disseminate and initiate the
formation of secondary tumors. However, it is still unclear how these migratory cells colonize
distant tissues to form macrometastases. The E6-associated protein, E6AP, acts both as an
E3 ubiquitin-protein ligase and as a coactivator of steroid hormone receptors. We report that …

… Following an institutional review by Peter MacCallum Cancer Center (Victoria, Australia),
the primary affiliation for several of the authors, it was not possible to confidently identify and
assign the primary datasets to support the data presented in multiple parts of Figs. 1–6
inclusive. As a result of these findings, the institution recommended retraction and, upon
internal review, the editors agree with this recommendation. … The E3-ligase E6AP
represses breast cancer metastasis via regulation of ECT2-Rho signaling … Citing articles via …