Pluripotent medicinal plants and their derivatives were famous spices and flavoring ingredients widely used in cooking and can be incorporated into different varieties of lifestyle as antioxidants and antimicrobial agents. The purpose of this project was to investigate the inhibitory properties of oak, cinnamon, oregano and thyme extracts on multidrug resistant and biofilm producing Klebsiella pneumoniae strains isolated from clinical mastitis cases in Baghdad. The statistical and scientific designing of this project depends on detection of ESBL producing K. pneumoniae strains from mastitis cases in regions of Abu-Ghraib, Al-Fudhaliyah and Al-Sadrya; via culturing and biochemical series confirmation tests. Extract disc sensitivity test, Kirby-Bauer technique using Carbapenems (Imipenem and Meropenem) with Oxoid Cefpodoxime Combination double diffusion inhibition kit using Muller-Hinton agar and McFarland turbidity tubes for checking antibiotic susceptibility pattern of isolates depending on instructions of USFDA Clinical Laboratory Standards Institute (CLSI). Preparation of crude concentrated and diluted, double distillated or purified extracts of locally collected and imported oak, cinnamon, oregano and thyme barks, leaves and nuts from different regions in Baghdad as watery and oily or alcoholic extracts according to recommendations of Codex international standards of Association of Official Agricultural Chemists (AOAC). Totally collected milk samples from mastitic Cows were thirty: ten samples from each region from January to April (2017), in which they processed according to modified food microbiological methods. Serum bactericidal power, minimum inhibitory concentration and minimum bactericidal concentration (MIC & MBC), Haemolysis pattern and Siderophore activity were checked using modified procedures. Chi-square analysis via SPSS software was applied for checking significant differences. The results revived detection of five (16.66%) isolates of K. pneumoniae out of thirty samples: three (10%) from Abu-Ghraib region and one (3.33%) from each Al-Fudhaliyah and Al-Sadrya regions, in which ESBL producers were only detected from Abu-Ghraib cases as totally three (10%) isolates themselves. Pluripotent Oak (Baloot), Cinnamon, Oregano and Thyme Extracts exhibit inhibitory effects on isolated strains of K. pneumoniae compared to selected antibiotics. These selective toxicity properties reflex their active ingredients that interacts directly and indirectly in different mechanisms with electromagnetic cloud (biofilm complex layers) of these multidrug resistant clinical isolates.