… Unlike smaller cargo that interacts with cellular NTRs to achieve nuclear entry, we propose
that the HIV-1 core, comprised of multimeric CA in association with the viral nucleic acid and …

… HIV-1 capsid influences viral uncoating and nuclear import. Some capsid is detected in the
… core, inhibiting nuclear transport of HIV-1 PICs without altering reverse transcription [18, 40] …

… intracellular capsid trafficking after viral fusion, nuclear import, … by Nup358 could destabilize
the capsid core by causing cis-to-… on Retroviruses and Opportunistic Infections, Seattle, WA, …

… more complex structures, such as capsid tubes or incoming cores in the context of infection.
… of assembled viral cores, or to areas of distinct curvature type across capsid shells, such as …

… nuclear import/entry step of HIV-1 infection. Emerging evidence also supports the functional
role of CA in the post-nuclear entry steps of infection, such as HIV-1 … core of the HIV-1 capsid …

… Collectively, these findings implicate the HIV-1 CA hexameric lattice … nuclear transport
receptor (NTR) that exploits soluble host 34 factors to modulate NPC requirements during nuclear …

… Another important host cell factor that plays a part in the nuclear import for the core of HIV-1
is the transportin-3 protein (TNPO3, also called TRN-SR2). It was initially thought to interact …

… captured by nuclear transport receptors (NTRs). Here we show that HIV-1 capsid assemblies
… Like NTRs, the capsid readily partitions into an in vitro assembled cohesive FG phase that …

… Next, the core containing viral genomic RNA is released into the cytoplasm. Reverse …
Second, although viral capsid uncoating is likely a prerequisite for nuclear import, specific …

… Viruses are opportunistic pathogens that infect a host by attacking their … the principles of
cellular nuclear transport, discuss the … In summary, HBV capsids use the cellular nuclear import …