[HTML][HTML] The IFN-γ–p38, ERK kinase axis exacerbates neutrophilic chronic rhinosinusitis by inducing the epithelial-to-mesenchymal transition
M Lee, DW Kim, R Khalmuratova, SH Shin, YM Kim… - Mucosal …, 2019 - Elsevier
Chronic rhinosinusitis (CRS) is a heterogeneous and multifactorial inflammatory disease
characterized by involvement of diverse types of inflammatory cells. Asian CRS patients
frequently show infiltration of neutrophils and an elevated level of interferon (IFN)-γ; by
contrast, western patients exhibit eosinophil infiltration and enhanced levels of Th2-related
cytokines. Neutrophilia in tissues decreases sensitivity to corticosteroids, but the
mechanisms underlying the progression of neutrophilic CRS are unclear. In this study, we …
characterized by involvement of diverse types of inflammatory cells. Asian CRS patients
frequently show infiltration of neutrophils and an elevated level of interferon (IFN)-γ; by
contrast, western patients exhibit eosinophil infiltration and enhanced levels of Th2-related
cytokines. Neutrophilia in tissues decreases sensitivity to corticosteroids, but the
mechanisms underlying the progression of neutrophilic CRS are unclear. In this study, we …
以上显示的是最相近的搜索结果。 查看全部搜索结果