Ensuring the user comfort and privacy in the Healthcare Information System (HIS) plays essential roles to accept and use any of HISs. This proposal aims to explore and examine the influence of users privacy and discomfort on using the HIS and applications which have been developed by the Saudi Ministry of Health (SMOH). The in-depth understanding of both factors is critical for large-scale acceptance of electronic health services. The researcher will conduct a quantitative research to achieve this aim and the Technology Acceptance Model (TAM) will be used to guide the research. Questioners will be distributed to collect the data from selected hospitals and primary healthcare centers within the Kingdom of Saudi Arabia (KSA). The researcher will use the SPSS Statistics software to analyze the primary data statistically. As an implication, examining of HISs implementation on why and how users accept them will help healthcare decision makers to understand the impact of human factors on using their system and mitigate user discomfort and privacy issue concerns. The study results would expand an area of healthcare systems and applications in the KSA, which is still empirically not adequately explored.