… By contrast, deacetylation is mediated by histone deacetylases (… concentrations of NAD ÷
are high, and SIRT1 activity is … this metabolic requirement is translated into an epigenetic code …

… The deacetylase sirtuin-1 (SIRT1) is known to mediate the … metabolism through the
deacetylation of metabolic regulators. … as regulators of gene expression and participate in …

… Deacetylation converts euchromatin to … This deacetylase enzyme is observed to be
significantly downregulated in endothelial cells exposed to high glucose [87]. In addition, SIRT1 is …

… information that could be translated to better treatment options. … shown that tubular Sirt1
attenuates albuminuria by epigenetic … Furthermore, deacetylase activity of Sirt1 was not required …

… genetic and epigenetic adaptations affecting energy metabolism are more … -CoA and
deacetylated by the class III deacetylase Sirt1. … A novel role for mitochondria in regulating …

… impact on the epigenetic regulation of metabolically relevant … as different classes of histone
deacetylases (HDACs), and … nutrition depletion increases SIRT1 and SIRT3 expression in …

… into ΔP and the efficiency by which complex V converts ΔP … They can be reactivated by
deacetylation by Sirt1 + NAD + . … genes, either genetic or epigenetic. Mutations in the mtDNA are …

… epigenetic alterations may contribute to the development of NAFLD by regulating genes
involved in lipid metabolism, … some of these epigenetic effectors, such as DNMT1, SIRT1, SIRT3, …

… Indeed, the worldwide prevalence of CKD is 3–18%, translating to 500 million patients [8]. In
… Specifically, SIRT1 and SIRT3 protect cardiomyocytes from stress [80]. Histone deacetylase …

… 1 (Sirt1), a histone deacetylase, plays a role in responses to starvation stress in Drosophila
4 . However, except for Sirt1, the epigenetic … amino acids for translation or energy generation …