Controlling cholesterol levels is a major challenge in human health, since
hypercholesterolemia can lead to serious cardiovascular disease. Drugs that target
carbohydrate metabolism can also modify lipid metabolism and hence cholesterol plasma
levels. In this sense, dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK)
inhibitor, augments usage of the glycolysis-produced pyruvate in the mitochondria
increasing oxidative phosphorylation (OXPHOS). In several animal models, DCA decreases …

Controlling cholesterol levels is a major challenge in human health, since
hypercholesterolemia can lead to serious cardiovascular disease. Drugs that target glucidic
metabolism can also modify lipid metabolism and hence cholesterol plasma levels. In this
sense, dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, augments
pyruvate usage in the mitochondria increasing oxidative phosphorylation (OXPHOS), but,
also, decreases cholesterol and triglycerides in animal models. Thus, DCA was used in the …