… (WT) and T513E PDK1 PH domains to lipid … PH domain shows that the PIP 3 -bound WT
PH domain on membranes is predominantly dimeric while the PIP 3 -bound T513E PH domain …

… As in other PH domains, the PDK1 PH domain is bound to the … S1) shows that the complex
system has stable dynamical behavior. The PH domain is more mobile than the KD domain in …

… Phosphoinositide-Dependent Kinase-1 (PDK1) is an essential master kinase recruited to the
plasma membrane by the binding of its C-terminal PH domain to … PDK1 has been shown to …

… using fluorescently tagged PH domains of PDK1 (PH PDK1 ). … Figure 5D shows a similar
effect for SGK1: We observed the … , would enable defining a novel therapeutic strategy where a …

… )-dependent signaling pathway has long been recognized as a … ), C-terminal (C) or PH
domain (PH) constructs were lysed, and the … the mechanism underlying this novel feedback loop. …

… PDK1 and AKT1 possess a PIP 3 -specific PH domain and exhibit stable binding to a …
In cellular settings, the novel role of PKCα as an inhibitor of PDK1-AKT1 phosphoactivation …

… master regulator phosphoinositide-dependent kinase 1 (PDK1… the PDK1 kinase domain in
relation to its PH domain. Finally, … novel 2 (PKN2) (via PIF docking to the PDK1 kinase domain …

… Finally, we show that PDK1 is autoinhibited by its PH domain and that … In the dimer, we
observed 36 novel crosslinks between … Effect of phosphoinositide-dependent kinase 1 on protein …

… PKCα exhibits eightfold higher PDK1 affinity than AKT1 and … The resulting PIP 3 recruits the
PH domains of PDK1 and AKT1 … homology domain: activation parameters and novel search …