The Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase-mammalian
target of rapamycin (PI3K-mTOR) signaling pathways are the chief mechanisms …

… induce intracellular PI3K/mTOR pathway signaling. Activation of … negative regulation of the
PI3K/mTOR pathway via inhibition of … results in upregulation of PI3K-mediated signaling (1–5). …

The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway
is activated in the majority of human cancers. This pathway is known to play a key role in …

… between activation of the PI3K/mTOR/AKT pathway (defined as … components of the PI3K/mTOR
pathway (group subtype). … of activation of the PI3K/mTOR/AKT pathway. Odds ratios for …

… all point to a dependence on PI3K/mTOR pathway activation in OS. To our knowledge, this
is the first study to report genomic alterations in PI3K/mTOR pathway members in a significant …

… The third generation of compounds comprises the so-called “dual PI3K/mTOR inhibitors.”
These were developed after consideration that the CAT sites of PI3K and mTOR share a high …

… Of special interest for BCR-ABL transformation is the requirement for an active PI3K/mTOR
pathway in the induction of elevated levels of intracellular ROS. This is consistent with …

… The alterations of this pathway make the PI3K pathway an attractive therapeutic … pathway,
such as PI3K/AKT inhibitors, rapamycin analogs for mTOR inhibition, and dual PI3K/mTOR …

… Essential PI3K/mTOR signaling pathway activation has been observed in most breast cancers.
The cell growth and tumor development in such cases involve phosphoinositide 3 kinase (…

… The dual PI3K-mTOR inhibitors target the p110 subunit of … , an oral dual inhibitor of
PI3K/mTOR. Stable disease in 12 … GDC-0980 is a dual PI3K/mTOR inhibitor that targets all PI3K …