The SMN Tudor SIM-like domain is key to SmD1 and coilin interactions and to Cajal body biogenesis
Cajal bodies (CBs) are nuclear organelles involved in the maturation of spliceosomal small
nuclear ribonucleoproteins (snRNPs). They concentrate coilin, snRNPs and the survival
motor neuron protein (SMN). Dysfunction of CB assembly occurs in spinal muscular atrophy
(SMA). Here, we demonstrate that SMN is a SUMO1 target that has a small ubiquitin-related
modifier (SUMO)-interacting motif (SIM)-like motif in the Tudor domain. The expression of
SIM-like mutant constructs abolishes the interaction of SMN with the spliceosomal SmD1 …
nuclear ribonucleoproteins (snRNPs). They concentrate coilin, snRNPs and the survival
motor neuron protein (SMN). Dysfunction of CB assembly occurs in spinal muscular atrophy
(SMA). Here, we demonstrate that SMN is a SUMO1 target that has a small ubiquitin-related
modifier (SUMO)-interacting motif (SIM)-like motif in the Tudor domain. The expression of
SIM-like mutant constructs abolishes the interaction of SMN with the spliceosomal SmD1 …
The SMN Tudor SIM-like domain is key to SmD1 and coilin interactions and to Cajal body biogenesis
O Tapia Martínez, V Lafarga, AR Palanca Cuñado… - 2014 - repositorio.unican.es
Cajal bodies (CBs) are nuclear organelles involved in the maturation of spliceosomal small
nuclear ribonucleoproteins (snRNPs). They concentrate coilin, snRNPs and the survival
motor neuron protein (SMN). Dysfunction of CB assembly occurs in spinal muscular atrophy
(SMA). Here, we demonstrate that SMN is a SUMO1 target that has a small ubiquitin-related
modifier (SUMO)-interacting motif (SIM)-like motif in the Tudor domain. The expression of
SIM-like mutant constructs abolishes the interaction of SMN with the spliceosomal SmD1 …
nuclear ribonucleoproteins (snRNPs). They concentrate coilin, snRNPs and the survival
motor neuron protein (SMN). Dysfunction of CB assembly occurs in spinal muscular atrophy
(SMA). Here, we demonstrate that SMN is a SUMO1 target that has a small ubiquitin-related
modifier (SUMO)-interacting motif (SIM)-like motif in the Tudor domain. The expression of
SIM-like mutant constructs abolishes the interaction of SMN with the spliceosomal SmD1 …
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