The Slit receptor Robo1 is predominantly expressed via the Dutt1 alternative promoter in pioneer neurons in the embryonic mouse brain and spinal cord
HF Nural, WT Farmer, GS Mastick - Gene Expression Patterns, 2007 - Elsevier
Robo1 is a member of the Roundabout (Robo) family of receptors for the Slit axon guidance
cues. In mice (and humans), the Robo1 locus has alternative promoters producing two
transcript isoforms, Robo1 and Dutt1. These isoforms have unique 5′ termini, predicted to
encode distinct N-terminal amino acids, but share the rest of their 3′ exons. To determine
the spatial expression of the Robo1 and Dutt1 isoforms, we generated isoform-specific RNA
probes, and carried out in situ hybridization on E10. 5 mouse embryos, the stage in early …
cues. In mice (and humans), the Robo1 locus has alternative promoters producing two
transcript isoforms, Robo1 and Dutt1. These isoforms have unique 5′ termini, predicted to
encode distinct N-terminal amino acids, but share the rest of their 3′ exons. To determine
the spatial expression of the Robo1 and Dutt1 isoforms, we generated isoform-specific RNA
probes, and carried out in situ hybridization on E10. 5 mouse embryos, the stage in early …
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