The Zα2 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development
S Kesavardhana, RKS Malireddi, AR Burton… - Journal of Biological …, 2020 - ASBMB
Z-DNA-binding protein 1 (ZBP1) is an innate immune sensor of nucleic acids that regulates
host defense responses and development. ZBP1 activation triggers inflammation and
pyroptosis, necroptosis, and apoptosis (PANoptosis) by activating receptor-interacting
Ser/Thr kinase 3 (RIPK3), caspase-8, and the NLRP3 inflammasome. ZBP1 is unique
among innate immune sensors because of its N-terminal Zα1 and Zα2 domains, which bind
to nucleic acids in the Z-conformation. However, the specific role of these Zα domains in …
host defense responses and development. ZBP1 activation triggers inflammation and
pyroptosis, necroptosis, and apoptosis (PANoptosis) by activating receptor-interacting
Ser/Thr kinase 3 (RIPK3), caspase-8, and the NLRP3 inflammasome. ZBP1 is unique
among innate immune sensors because of its N-terminal Zα1 and Zα2 domains, which bind
to nucleic acids in the Z-conformation. However, the specific role of these Zα domains in …