The activities of GST isozymes in stomach tissues of female obese patients
C Yilmaz, H Bulus, S Oguztuzun, M Cihan… - Turkish Journal of …, 2020 - degruyter.com
Turkish Journal of Biochemistry, 2020•degruyter.com
Objectives Obesity has become an important public health problem because of its
increasing prevalence and relation with many diseases and mortality. Studies have shown
its association with oxidative stress. In this study, the effect of obesity on total amount of thiol
and some glutathione S-transferase (GST) isozymes were investigated which could serve as
an important criteria in dose adjustment of some certain drugs in obese. Methods The gastric
tissues removed by gastrectomy operation from 29 morbid obese female patients were …
increasing prevalence and relation with many diseases and mortality. Studies have shown
its association with oxidative stress. In this study, the effect of obesity on total amount of thiol
and some glutathione S-transferase (GST) isozymes were investigated which could serve as
an important criteria in dose adjustment of some certain drugs in obese. Methods The gastric
tissues removed by gastrectomy operation from 29 morbid obese female patients were …
Objectives
Obesity has become an important public health problem because of its increasing prevalence and relation with many diseases and mortality. Studies have shown its association with oxidative stress. In this study, the effect of obesity on total amount of thiol and some glutathione S-transferase (GST) isozymes were investigated which could serve as an important criteria in dose adjustment of some certain drugs in obese.
Methods
The gastric tissues removed by gastrectomy operation from 29 morbid obese female patients were analysed for thiol levels and activities of total GST, GSTT1-1 and GSTM1-1. Patients were grouped according to age, presence of hypertension and/or diabetes, and family history.
Results
The average total thiol was 131.22 (±7.74) nmol/mg protein with no significant differences in between the groups. GSTT1 specific activities were about 20% higher in four groups: with ages over 35 years old, with hypertension, without diabetes and finally without family history, with respect to other groups. The differences between total GST and GSTM1 activity levels of experimental groups were not significant.
Conclusions
This is the first study to compare activities of GST isozymes and total thiol content in the stomach tissues of obese female patients accompanying some common metabolic disorders, age and family history.
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