The association between knee osteoarthritis and HLA-DRB1* 0101 in the east of Iran
O Kooshkaki, E Atabati, M Shayesteh… - Current …, 2020 - ingentaconnect.com
O Kooshkaki, E Atabati, M Shayesteh, F Salmani, GA Sarab
Current Rheumatology Reviews, 2020•ingentaconnect.comBackground: Osteoarthritis (OA) is a painful social problem, which breaks down the articular
cartilage, causes the failure of synovial joints and subchondral bone sclerosis. OA etiology is
not completely understood, but joint trauma, infection, obesity, and diseases are the most
important risk factors for OA developing. Recent studies suggested inflammatory factors and
genetic components can be involved in the pathogenesis of OA. Experimental evidences
suggest a linkage between Human Leukocyte Antigen (HLA) genetic diversity and OA. But a …
cartilage, causes the failure of synovial joints and subchondral bone sclerosis. OA etiology is
not completely understood, but joint trauma, infection, obesity, and diseases are the most
important risk factors for OA developing. Recent studies suggested inflammatory factors and
genetic components can be involved in the pathogenesis of OA. Experimental evidences
suggest a linkage between Human Leukocyte Antigen (HLA) genetic diversity and OA. But a …
Background
Osteoarthritis (OA) is a painful social problem, which breaks down the articular cartilage, causes the failure of synovial joints and subchondral bone sclerosis. OA etiology is not completely understood, but joint trauma, infection, obesity, and diseases are the most important risk factors for OA developing. Recent studies suggested inflammatory factors and genetic components can be involved in the pathogenesis of OA. Experimental evidences suggest a linkage between Human Leukocyte Antigen (HLA) genetic diversity and OA. But a few studies have been conducted in this subject.
Objective
To investigate the association between HLA-DRB1*0101 and OA in Iranian patients.
Methods
Thirty patients with knee osteoarthritis and 30 healthy people as the control group were included in the study. Sex, weight, age, Body mass index (BMI) and height of all participants were recorded. HLA-DRB1*0101 was typed by PCR using the sequence-specific primer.
Results
Our results showed 80% of knee osteoarthritis patients were positively HLA-DRB1*0101 (n=24), while only 26.7% of controls were positive (n=8) (P= 0.015).
Conclusion
These findings proposed that there is a significant association between HLADRB1* 0101 and susceptibility to knee osteoarthritis.
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