The carboxyl termini of β-amyloid peptides 1-40 and 1-42 are generated by distinct γ-secretase activities
HW Klafki, D Abramowski, R Swoboda… - Journal of Biological …, 1996 - ASBMB
We have studied the effects of peptide aldehyde protease inhibitors on the secretion of β-
amyloid peptide 1-40 (Aβ (1-40)) and Aβ (1-42) by HEK 293 and COS-1 cells expressing β-
amyloid precursor protein with the Swedish double mutation. A multiphasic SDS-
polyacrylamide gel electrophoresis system was used for the discrimination of Aβ (1-40) and
Aβ (1-42). Calpain inhibitor I, carbobenzoxyl-Leu-Leu-leucinal, and calpeptin were found to
reduce the amount of Aβ (1-40) released into the medium in a dose-dependent manner. The …
amyloid peptide 1-40 (Aβ (1-40)) and Aβ (1-42) by HEK 293 and COS-1 cells expressing β-
amyloid precursor protein with the Swedish double mutation. A multiphasic SDS-
polyacrylamide gel electrophoresis system was used for the discrimination of Aβ (1-40) and
Aβ (1-42). Calpain inhibitor I, carbobenzoxyl-Leu-Leu-leucinal, and calpeptin were found to
reduce the amount of Aβ (1-40) released into the medium in a dose-dependent manner. The …
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