The circadian clock regulates RPE-mediated lactate transport via SLC16A1 (MCT1)
N Milićević, JB Ten Brink, ALMA Ten Asbroek… - Experimental eye …, 2020 - Elsevier
Multiple retinal cells harbor a circadian oscillator, including retinal pigment epithelial cells
(RPE). However, little is known about the functions that are regulated by the RPE clock. The
aim of this study was to investigate whether the circadian clock in the RPE regulates the
transport of glucose and its glycolytic metabolic by-product-lactate. To that end, we first
characterized the mRNA expression profile of glucose and monocarboxylate transporters in
ARPE-19 cells. We found that SLC2A1 and SLC16A1 were, respectively, the most …
(RPE). However, little is known about the functions that are regulated by the RPE clock. The
aim of this study was to investigate whether the circadian clock in the RPE regulates the
transport of glucose and its glycolytic metabolic by-product-lactate. To that end, we first
characterized the mRNA expression profile of glucose and monocarboxylate transporters in
ARPE-19 cells. We found that SLC2A1 and SLC16A1 were, respectively, the most …
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