The clinical significance of serum miRNA-224 expression in hepatocellular carcinoma
Results The relative expression of serum miRNA-224 was significantly higher in HCC
patients compared to LC patients and healthy control subjects. Its level correlated positively
with the serum concentration of AFP and with Barcelona Clinic Liver Cancer (BCLC) stage of
HCC. By combining miRNA-224 relative expression with AFP, their diagnostic sensitivity,
specificity and accuracy increased significantly (95.0%, 92.1% and 93.2%, respectively)
compared with either of the two markers alone in discriminating HCC from liver cirrhosis …
patients compared to LC patients and healthy control subjects. Its level correlated positively
with the serum concentration of AFP and with Barcelona Clinic Liver Cancer (BCLC) stage of
HCC. By combining miRNA-224 relative expression with AFP, their diagnostic sensitivity,
specificity and accuracy increased significantly (95.0%, 92.1% and 93.2%, respectively)
compared with either of the two markers alone in discriminating HCC from liver cirrhosis …
Results
The relative expression of serum miRNA-224 was significantly higher in HCC patients compared to LC patients and healthy control subjects. Its level correlated positively with the serum concentration of AFP and with Barcelona Clinic Liver Cancer (BCLC) stage of HCC. By combining miRNA-224 relative expression with AFP, their diagnostic sensitivity, specificity and accuracy increased significantly (95.0%, 92.1% and 93.2%, respectively) compared with either of the two markers alone in discriminating HCC from liver cirrhosis.
Conclusions
Serum miRNA-224 relative expression may aid in the diagnosis of HCC. Better diagnostic performance is obtained if miRNA-224 is combined with other tumor markers such as AFP.
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