During the Middle Horizon (AD 650–1000), the Wari polity expanded its sphere of control in various regions of the Andes, including Nasca on the south coast of Peru. The nature of the interaction between Wari and local communities varied. This study explores the consequences of Wari contact in the Nasca region at the site of La Tiza, which includes individuals dated to the Early Intermediate, Middle Horizon, and Late Intermediate periods. Using evidence for burial ritual along with demographic, paleopathological and isotopic data, population composition, mobility, diet, and health are investigated. δ¹³C data indicate a relatively stable diet through time at La Tiza with evidence for continued maize consumption, and paleopathological results indicate health problems associated with this type of diet. δ¹⁸O and ⁸⁷Sr/⁸⁶Sr data suggest that most of the individuals buried at La Tiza were local to the area. However, two female adults from the Middle Horizon burials are characterized as nonlocal based on δ¹⁸O and ⁸⁷Sr/⁸⁶Sr values and several individuals overlap with the ⁸⁷Sr/⁸⁶Sr local range for the Wari heartland. In conjunction with the use of new tomb types during this period these results highlight the ideological and populational changes occurring with Wari contact at La Tiza.