The electrical response of muscle to repetitive nerve stimulation was studied in patients with various myotonic disorders. A decrementing response was a common but not invariable finding, and was unrelated to the severity or diagnosis. The decrement either continued throughout the period of stimulation or “leveled off,” sometimes being followed by an increment. If it occurred at low rates of stimulation, a greater decrement occurred at higher rates, usually after a shorter latent period. It was not related consistently to the presence of weakness, but in patients with myotonia congenita it was more conspicuous and elicited by lower rates of stimulation when transient weakness was a feature of the history.