The dietary biogenic amines tyramine and histamine show synergistic toxicity towards intestinal cells in culture
Tyramine and histamine are the biogenic amines (BA) most commonly found at high
concentrations in food; they may even appear together at toxic concentrations. The present
work examines, via real-time cell analysis, whether histamine and tyramine show synergistic
toxicity towards intestinal cell cultures. Employing a constant equipotency ratio, their
interaction was examined via the combination index (CI) method of Chou & Talalay. Co-
treatment with tyramine and histamine was associated with a stronger cytotoxic effect than …
concentrations in food; they may even appear together at toxic concentrations. The present
work examines, via real-time cell analysis, whether histamine and tyramine show synergistic
toxicity towards intestinal cell cultures. Employing a constant equipotency ratio, their
interaction was examined via the combination index (CI) method of Chou & Talalay. Co-
treatment with tyramine and histamine was associated with a stronger cytotoxic effect than …
The dietary biogenic amines tyramine and histamine show synergistic toxicity towards intestinal cells in culture
B Río Lagar, B Redruello, DM Linares… - 2017 - digital.csic.es
Tyramine and histamine are the biogenic amines (BA) most commonly found at high
concentrations in food; they may even appear together at toxic concentrations. The present
work examines, via real-time cell analysis, whether histamine and tyramine show synergistic
toxicity towards intestinal cell cultures. Employing a constant equipotency ratio, their
interaction was examined via the combination index (CI) method of Chou & Talalay. Co-
treatment with tyramine and histamine was associated with a stronger cytotoxic effect than …
concentrations in food; they may even appear together at toxic concentrations. The present
work examines, via real-time cell analysis, whether histamine and tyramine show synergistic
toxicity towards intestinal cell cultures. Employing a constant equipotency ratio, their
interaction was examined via the combination index (CI) method of Chou & Talalay. Co-
treatment with tyramine and histamine was associated with a stronger cytotoxic effect than …
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