The dynamics of acute inflammation

R Kumar, G Clermont, Y Vodovotz, CC Chow - Journal of theoretical …, 2004 - Elsevier
When the body is infected, it mounts an acute inflammatory response to rid itself of the
pathogens and restore health. Uncontrolled acute inflammation due to infection is defined
clinically as sepsis and can culminate in organ failure and death. We consider a three-
dimensional ordinary differential equation model of inflammation consisting of a pathogen,
and two inflammatory mediators. The model reproduces the healthy outcome and diverse
negative outcomes, depending on initial conditions and parameters. We analyze the various …
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