The effect of GLT-1 upregulation on extracellular glutamate dynamics

CM Wilkie, JC Barron, KJ Brymer, JR Barnes… - Frontiers in Cellular …, 2021 - frontiersin.org
Pharmacological upregulation of glutamate transporter-1 (GLT-1), commonly achieved using
the beta-lactam antibiotic ceftriaxone, represents a promising therapeutic strategy to
accelerate glutamate uptake and prevent excitotoxic damage in neurological conditions.
While excitotoxicity is indeed implicated in numerous brain diseases, it is typically restricted
to select vulnerable brain regions, particularly in early disease stages. In healthy brain
tissue, the speed of glutamate uptake is not constant and rather varies in both an activity-and …

[引用][C] The Effect of GLT-1 Upregulation on Extracellular Glutamate Dynamics. Front Cell Neurosci [Internet]. 2021 [cited 2021 Jun 29]; 15

CM Wilkie, JC Barron, KJ Brymer, JR Barnes, F Nafar…
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