The effect of adrenomedullin and cold stress on interleukin-6 levels in some rat tissues

NC Yildirim, M Yurekli - Clinical & Experimental Immunology, 2010 - academic.oup.com
Stress known to stimulate sympathetic activity, as well as the hypothalamic–pituitary–
adrenal axis (HPA), produces a significant increase in adrenomedullin (AdM) levels,
suggesting a regulatory or protective role for AdM in countering HPA activation that follows a
variety of stressors. Stressors can modulate the secretion of proinflammatory cytokines.
Interleukin (IL)-6 is a potent activator of the HPA and appears to play a pathogenic role in
conditions related to stress. In the present study, we investigated the administration of AdM …

[PDF][PDF] The effect of adrenomedullin and cold stress on interleukin-6 levels in some rat tissuescei_4156 171.. 175

NC Yildirim, M Yurekli - AdM - academia.edu
Stress known to stimulate sympathetic activity, as well as the hypothalamic–pituitary–
adrenal axis (HPA), produces a significant increase in adrenomedullin (AdM) levels,
suggesting a regulatory or protective role for AdM in countering HPA activation that follows a
variety of stressors. Stressors can modulate the secretion of proinflammatory cytokines.
Interleukin (IL)-6 is a potent activator of the HPA and appears to play a pathogenic role in
conditions related to stress. In the present study, we investigated the administration of AdM …
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