[HTML][HTML] The effect of dietary nitrate and vitamin C on endothelial function, oxidative stress and blood lipids in untreated hypercholesterolemic subjects: A randomized …

R Basaqr, M Skleres, R Jayswal, DT Thomas - Clinical Nutrition, 2021 - Elsevier
Background Vitamin C may enhance nitric oxide (NO) production through stepwise
reduction of dietary nitrate (NO 3) to nitrite (NO 2) to NO. The combined effect of vitamin C
and NO 3 supplementation is relatively unexplored in untreated hypercholesterolemia. Aims
We aimed to examine whether co-administration of vitamin C and nitrate for 4-weeks would
improve endothelial function (primary outcome), plasma NO metabolites, oxidative stress,
and blood lipids (secondary outcomes). Methods Subjects 50–70 years of age with low …
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