The effects of angiotensin-II receptor blockers on podocyte damage and glomerular apoptosis in a rat model of experimental streptozotocin-induced diabetic …
M Tunçdemir, M Öztürk - Acta histochemica, 2011 - Elsevier
The aim of the study was to determine in a rat model of streptozotocin-induced diabetic
nephropathy the expression of: WT-1 (for podocyte loss in the glomerulus), TGF-beta 1 (for
tissue damage), caspase-3 and bax (for glomerular apoptosis) and the possible protective
effects of an angiotensin II type 1 receptor blocker. Three groups of male Wistar albino rats
were used. The first group consisted of non-diabetic control rats. The second group was the
untreated diabetic rats. The third group consisted of diabetic rats treated with Irbesartan …
nephropathy the expression of: WT-1 (for podocyte loss in the glomerulus), TGF-beta 1 (for
tissue damage), caspase-3 and bax (for glomerular apoptosis) and the possible protective
effects of an angiotensin II type 1 receptor blocker. Three groups of male Wistar albino rats
were used. The first group consisted of non-diabetic control rats. The second group was the
untreated diabetic rats. The third group consisted of diabetic rats treated with Irbesartan …
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