The effects of chronic zoledronate usage on the jaw and long bones evaluated using RANKL and osteoprotegerin levels in an animal model
The discovery of the receptor activator of nuclear factor kappaB (RANK), RANK ligand
(RANKL), and osteoprotegerin (OPG) system (RANK/RANKL/OPG system) has been one of
the most important advances in bone biology in the last decade. We investigated how the
chronic application of bisphosphonate affects the RANKL and OPG levels in an animal
model and whether this effect may be related to bisphosphonate-related osteonecrosis of
the jaws (BRONJ). Thirty female Sprague–Dawley rats were used in this study. The rats …
(RANKL), and osteoprotegerin (OPG) system (RANK/RANKL/OPG system) has been one of
the most important advances in bone biology in the last decade. We investigated how the
chronic application of bisphosphonate affects the RANKL and OPG levels in an animal
model and whether this effect may be related to bisphosphonate-related osteonecrosis of
the jaws (BRONJ). Thirty female Sprague–Dawley rats were used in this study. The rats …
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