Accepted: Apr 20, 2014; Published: May 8, 2014 Abstract: The effect of ethanol stem extract of Desmodium velutinum on some liver enzymes of albino Wistar rats fed with high fat diet was analyzed. Twenty four healthy albinoWistar rats were divided into four groups of six rats each. Group I rats were fed with normal feed, group II rats were fed with 10mg/ml of high fat diet, group III rats received 10mg/ml of high fat diet+ 5mg/kg of atorvastatin while group IV rats were fed with 10mg/ml of high fat diet+ 5mg/kg of ethanol stem extract of Desmodium velutinum. The rats were sacrificed at the end of the experiments which lasted for two weeks. The results showed that ethanol stem extract of Desmodium velutinum possesse shepato protective activity on the fatty liver of albino Wistar rat fed with high fat diet. Desmodium velutinum showed variable amount of phytochemicals including flavonoids, alkaloids, saponins, tannins and terpenoids which were determined quantitatively and qualitatively using standard methods. The significant effect of Desmodium velutinume than olstem extract was compared with that of standard drug atorvastatin and the result suggest that the ethanol stem extract of Desmodium velutinum could be used in the treatment of liver diseases.