The effects of micronutrient deficiencies on bacterial species from the human gut microbiota
Vitamin and mineral (micronutrient) deficiencies afflict 2 billion people. Although the impact
of these imbalances on host biology has been studied extensively, much less is known
about their effects on the gut microbiota of developing or adult humans. Therefore, we
established a community of cultured, sequenced human gut–derived bacterial species in
gnotobiotic mice and fed the animals a defined micronutrient-sufficient diet, followed by a
derivative diet devoid of vitamin A, folate, iron, or zinc, followed by return to the sufficient diet …
of these imbalances on host biology has been studied extensively, much less is known
about their effects on the gut microbiota of developing or adult humans. Therefore, we
established a community of cultured, sequenced human gut–derived bacterial species in
gnotobiotic mice and fed the animals a defined micronutrient-sufficient diet, followed by a
derivative diet devoid of vitamin A, folate, iron, or zinc, followed by return to the sufficient diet …
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