The effects of resistance exercise training followed by de-training on irisin and some metabolic parameters in type 2 diabetic rat model
H Tavassoli, A Heidarianpour… - Archives of physiology …, 2022 - Taylor & Francis
H Tavassoli, A Heidarianpour, M Hedayati
Archives of physiology and biochemistry, 2022•Taylor & FrancisBackground We investigated the effects of high-fat diet (HFD) consumption combined with
diabetes induction, resistance exercise training (RET) and a de-training period on circulating
irisin levels and selective metabolic parameters. Material and methods Rats were assigned
to four groups (n= 8): healthy non-diabetic rats (NDC), non-diabetic rats that performed RET
(NDR), sedentary HFD-fed/STZ-treated rats (HFD/STZ) and HFD-fed/STZ-treated rats that
performed RET (HFD/STZ+ RE). Results HFD consumption reduced irisin level and Quicki …
diabetes induction, resistance exercise training (RET) and a de-training period on circulating
irisin levels and selective metabolic parameters. Material and methods Rats were assigned
to four groups (n= 8): healthy non-diabetic rats (NDC), non-diabetic rats that performed RET
(NDR), sedentary HFD-fed/STZ-treated rats (HFD/STZ) and HFD-fed/STZ-treated rats that
performed RET (HFD/STZ+ RE). Results HFD consumption reduced irisin level and Quicki …
Background
We investigated the effects of high-fat diet (HFD) consumption combined with diabetes induction, resistance exercise training (RET) and a de-training period on circulating irisin levels and selective metabolic parameters.
Material and methods
Rats were assigned to four groups (n = 8): healthy non-diabetic rats (NDC), non-diabetic rats that performed RET (NDR), sedentary HFD-fed/STZ-treated rats (HFD/STZ) and HFD-fed/STZ-treated rats that performed RET (HFD/STZ + RE).
Results
HFD consumption reduced irisin level and Quicki (p < .01). After the 12-week period, levels of TC, TG, HOMA1-IR, HOMA2-IR and irisin were also lower in the HFD/STZ + RE group compared to the HFD/STZ group. Body weight and HOMA1-IR showed a positive (r = 0.558 and r = 0.538) whereas TC and LDL-C had a negative correlation (r = −0.461 and r = −0.630) with irisin level (p < .05).
Conclusions
Irisin level increased along with the progress of obesity and T2DM. It seems that RET can attenuate the increase of irisin in those conditions by improvement of glucose/lipid metabolic disorders.
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