The effects of the Fanconi anemia zinc finger (FAZF) on cell cycle, apoptosis, and proliferation are differentiation stage-specific
MS Dai, N Chevallier, S Stone, MC Heinrich… - Journal of Biological …, 2002 - ASBMB
FAZF, a member of the BTB/POZ family of transcriptional repressor proteins, has been
shown to bind to FANCC, the protein defective in patients with the bone marrow failure
syndrome Fanconi anemia complementation group C. Because bone marrow failure in
Fanconi anemia has been attributed to a failure of the hematopoietic stem cell population to
produce sufficient progeny, we documented the expression of FAZF in human CD34+
hematopoietic progenitor cells. FAZF was expressed at high levels in early stages of …
shown to bind to FANCC, the protein defective in patients with the bone marrow failure
syndrome Fanconi anemia complementation group C. Because bone marrow failure in
Fanconi anemia has been attributed to a failure of the hematopoietic stem cell population to
produce sufficient progeny, we documented the expression of FAZF in human CD34+
hematopoietic progenitor cells. FAZF was expressed at high levels in early stages of …
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