Preeclampsia is a common, pregnancy-specific syndrome defined by clinical findings of elevated blood pressure combined with proteinuria and edema. It is characterized by a generalized dysfunction of the maternal endothelium, as demonstrated by the increased levels of factor VIII, total and cellular fibronectin, thrombomodulin, endothelin and a disturbance of prostacyclin/thromboxane balance. The new concept of endothelial-platelet dysfunction shows the central role of endothelial cell and platelet: endothelial dysfunction, increased vascular reactivity and platelet activation. The aim of this review is to reveal the recent data regarding the role of endothelial-platelet dysfunction in the pathogenesis of preeclampsia.