The process of episiotomy surgery during childbirth results in injury and pain in the perineum. This study aims to evaluate the effect of the topical combination of cinnamon oil and red betel extract on the healing process of episiotomy incision model in Swiss mice. The research subjects were divided into six groups:(I) Negative control,(II) positive control,(III) mice treated with cinnamon oil,(IV) mice treated with red betel extract,(V) mice treated with 2 ml cinnamon oil and 20% red betel extract, and (VI) mice treated with 4 ml cinnamon oil and 40% red betel extract. Each group of mice received a full-thickness skin wound on the back. The incision wound was then applied by using gel two times a day for 5 days which had been prepared previously. The results showed that the combination of cinnamon oil and red betel decreased the area and percentage of the wound, decreased the inflammatory cell infiltration, and increased the vascular endothelial growth factor expression. This study concludes that the combination of cinnamon oil and red betel extract have the potential to accelerate wound healing and reduce perineal pain in episiotomy incision models conducted in Swiss mice.