Background Frailty index (FI) is a well-established predictor of all-cause mortality, but less is
known for cause-specific mortality and whether familial effects influence the associations.
Middle-aged individuals are also understudied for the association between FI and mortality.
Furthermore, the population mortality impact of frailty remains understudied. Methods We
estimated the predictive value of FI for all-cause and cause-specific mortality, taking into
account familial factors, and tested whether the associations are time-dependent. We also …

Background Frailty index (FI) is a well-established predictor of all-cause mortality, but less is
known for cause-specific mortality and whether familial effects influence the associations.
Furthermore, the population mortality impact of frailty remains understudied. Objectives To
estimate the predictive value of frailty for all-cause and cause-specific mortality, and to test
whether the associations are time-dependent. We also assessed the proportion of deaths
that are attributable to increased levels of frailty. Methods We analyzed 42,953 participants …