The human monocytic leukemia zinc finger histone acetyltransferase domain contains DNA-binding activity implicated in chromatin targeting
MA Holbert, T Sikorski, J Carten, D Snowflack… - Journal of Biological …, 2007 - ASBMB
The human monocytic leukemia zinc finger (MOZ) protein is an essential transcriptional
coactivator and histone acetyltransferase (HAT) that plays a primary role in the differentiation
of erythroid and myeloid cells and is required to maintain hematopoietic stem cells.
Chromosomal translocations involving the HAT-encoded region are also associated with
acute myeloid leukemia. Here we present the x-ray crystal structure of the MOZ HAT domain
and related biochemical studies. We find that the HAT domain contains a central region that …
coactivator and histone acetyltransferase (HAT) that plays a primary role in the differentiation
of erythroid and myeloid cells and is required to maintain hematopoietic stem cells.
Chromosomal translocations involving the HAT-encoded region are also associated with
acute myeloid leukemia. Here we present the x-ray crystal structure of the MOZ HAT domain
and related biochemical studies. We find that the HAT domain contains a central region that …