The hyaluronic acid–CD44 interaction in the physio-and pathological stem cell niche
I Sevic, DL Vitale, FM Spinelli… - Proteoglycans in Stem …, 2021 - Springer
Proteoglycans in Stem Cells: From Development to Cancer, 2021•Springer
The CD44 protein is a single-chain transmembrane glycoprotein able to bind several
ligands. Hyaluronic acid is its main ligand and this interaction is the most extensively
studied. Hyaluronic acid, as a component of the extracellular matrix, through CD44 is able to
modulate several mechanisms that control stem cell behavior, such as migration and
anchorage, efflux of toxic compounds, growth in hypoxic conditions and quiescence,
besides their self-renewal and differentiation potential. In this chapter we describe the …
ligands. Hyaluronic acid is its main ligand and this interaction is the most extensively
studied. Hyaluronic acid, as a component of the extracellular matrix, through CD44 is able to
modulate several mechanisms that control stem cell behavior, such as migration and
anchorage, efflux of toxic compounds, growth in hypoxic conditions and quiescence,
besides their self-renewal and differentiation potential. In this chapter we describe the …
Abstract
The CD44 protein is a single-chain transmembrane glycoprotein able to bind several ligands. Hyaluronic acid is its main ligand and this interaction is the most extensively studied. Hyaluronic acid, as a component of the extracellular matrix, through CD44 is able to modulate several mechanisms that control stem cell behavior, such as migration and anchorage, efflux of toxic compounds, growth in hypoxic conditions and quiescence, besides their self-renewal and differentiation potential. In this chapter we describe the hyaluronic acid–CD44 interaction as part of the communication between the extracellular matrix and different cells that belong to the stem niche, focusing on the hematopoietic and adipose niche. Finally, we discuss the role of these interactions in the transformation of the normal stem niche to a tumorigenic niche that allows the development of cancer stem cells.
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