[HTML][HTML] The immunoproteasome is induced by cytokines and regulates apoptosis in human islets
The Journal of endocrinology, 2017•ncbi.nlm.nih.gov
… We show that cytokines induce the expression and activity of the immuno-proteasome in
INS-1E cells and human islets. Cytokine-induced immuno-proteasome expression but not
activity depended upon histone deacetylase 3 activation. Inhibition of JAK1/STAT1
signaling did not affect proteasomal activity. Inhibition of the … 4A, these cytokines
significantly increased the proportion of apoptotic human islet cells, as identified by the
classical morphological criteria of chromatin condensation and/or blebs (Fig. 4B). This effect …
INS-1E cells and human islets. Cytokine-induced immuno-proteasome expression but not
activity depended upon histone deacetylase 3 activation. Inhibition of JAK1/STAT1
signaling did not affect proteasomal activity. Inhibition of the … 4A, these cytokines
significantly increased the proportion of apoptotic human islet cells, as identified by the
classical morphological criteria of chromatin condensation and/or blebs (Fig. 4B). This effect …
Abstract
Aims
In addition to degrading misfolded and damaged proteins, the proteasome regulates the fate of cells in response to stress. The role of the proteasome in pro-inflammatory cytokine-induced human beta-cell apoptosis is unknown.
ncbi.nlm.nih.gov
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