The inflammatory cytokine IL-3 hampers cardioprotection mediated by endothelial cell-derived extracellular vesicles possibly via their protein cargo
C Penna, S Femminò, M Tapparo, T Lopatina… - Cells, 2020 - mdpi.com
The biological relevance of extracellular vesicles (EV) released in an ischemia/reperfusion
setting is still unclear. We hypothesized that the inflammatory microenvironment prevents
cardioprotection mediated by endothelial cell (EC)-derived extracellular vesicles. The effects
of naïve EC-derived EV (eEV) or eEV released in response to interleukin-3 (IL-3)(eEV-IL-3)
were evaluated in cardiomyoblasts (H9c2) and rat hearts. In transwell assay, eEV protected
the H9c2 exposed to hypoxia/reoxygenation (H/R) more efficiently than eEV-IL-3 …
setting is still unclear. We hypothesized that the inflammatory microenvironment prevents
cardioprotection mediated by endothelial cell (EC)-derived extracellular vesicles. The effects
of naïve EC-derived EV (eEV) or eEV released in response to interleukin-3 (IL-3)(eEV-IL-3)
were evaluated in cardiomyoblasts (H9c2) and rat hearts. In transwell assay, eEV protected
the H9c2 exposed to hypoxia/reoxygenation (H/R) more efficiently than eEV-IL-3 …
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