The influence of simvastatin, atorvastatin and high-cholesterol diet on acetylcholinesterase activity, amyloid beta and cholesterol synthesis in rat brain
L Cibickova, H Radomir, M Stanislav, C Norbert… - Steroids, 2009 - Elsevier
OBJECTIVE: There is evidence to suppose that cholesterol-lowering medicine might confer
protection against dementia, probably via modulation of cholesterol synthesis in the brain.
The aim of the present study was to investigate the potential influence of statins and
cholesterol diet on selected parameters relevant to Alzheimer's disease pathophysiology.
METHODS: For 15 days, rats were orally administered simvastatin (10 or 20mg/kg b. wt.),
atorvastatin (10 or 20mg/kg b. wt.), or aqua (control group); and one group was fed high …
protection against dementia, probably via modulation of cholesterol synthesis in the brain.
The aim of the present study was to investigate the potential influence of statins and
cholesterol diet on selected parameters relevant to Alzheimer's disease pathophysiology.
METHODS: For 15 days, rats were orally administered simvastatin (10 or 20mg/kg b. wt.),
atorvastatin (10 or 20mg/kg b. wt.), or aqua (control group); and one group was fed high …