The legumain McPAL1 from Momordica cochinchinensis is a highly stable Asx-specific splicing enzyme
Legumains, also known as asparaginyl endopeptidases (AEPs), cleave peptide bonds after
Asn/Asp (Asx) residues. In plants, certain legumains also have ligase activity that catalyzes
biosynthesis of Asx-containing cyclic peptides. An example is the biosynthesis of MCoTI-I/II,
a squash family-derived cyclic trypsin inhibitor, which involves splicing to remove the N-
terminal prodomain and then N-to-C-terminal cyclization of the mature domain. To identify
plant legumains responsible for the maturation of these cyclic peptides, we have isolated …
Asn/Asp (Asx) residues. In plants, certain legumains also have ligase activity that catalyzes
biosynthesis of Asx-containing cyclic peptides. An example is the biosynthesis of MCoTI-I/II,
a squash family-derived cyclic trypsin inhibitor, which involves splicing to remove the N-
terminal prodomain and then N-to-C-terminal cyclization of the mature domain. To identify
plant legumains responsible for the maturation of these cyclic peptides, we have isolated …
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