Decorin is a small leucine-rich proteoglycan that modulates the activity of transforming
growth factor type β and other growth factors and thereby influences the processes of
proliferation and differentiation in a wide array of physiological and pathological reactions.
Hence, understanding the regulatory mechanisms of decorin activity has broad implications.
Here we report that the extracellular levels of decorin are controlled by receptor-mediated
catabolism, involving the low density lipoprotein receptor family member, low density …