The transcription factor CREB is best known for its involvement in learning and … CREB activity
has very different roles – sometimes beneficial, sometimes detrimental – depending on the …

… , and physiology, through the control of target gene expression. In this review, we highlight
the essential roles of CREB proteins in the nervous system, the immune system, cancer …

… The transcription factor CREB has been implicated in signalling pathways relevant for
pathogenesis and therapy of depression. CREB is upregulated and activated in the … using CREB-…

… To begin to explore the mechanism underlying the link between CREB and the … , we need
to identify the genes regulated by CREB after both short- and long-… The many faces of CREB …

… We present some of the classical intracellular signaling … to CREB activation and the crosstalk
among them. We also present the more recently discovered mechanisms controlling CREB …

… to the CREB transcription factor. This review attempts to illustrate how CREB, one of the first
… , implicating this factor in many neuronal functions, all the way from cell birth to cell death. …

… While evidence is sparse, studies also point to a dysfunction in CREB signaling with aging.
We propose that CREB may be a viable therapeutic target for the … The many faces of CREB …

… In response to signals at the cell surface, CREB is phosphorylated in the nucleus by
various protein kinases via secondary messengers such as cAMP and/or Ca+2 for regulating …

… We found that the virally manipulated CREB biased the allocation of memory to the transfected
… Notably, we also found that neurons with higher CREB levels were more excitable than …

… using the Cre/loxP system. Mice with a Crem −/− background and lacking Creb in the central
… We have used genetic disruption to study the function of the CREB family members. We …