An expert panel carried out a selected review of published literature regarding the mechanisms of action of the VAC device in the context of published clinical studies. The current literature suggests primary mechanisms of action of the VAC device may include the following:(1) drawing the wound edges together;(2) stabilization of the wound environment;(3) decrease in wound edema and removal of wound exudate; and (4) microdeformations of the wound surface. Secondary effects include increased angiogenesis, granulation tissue formation, and, in some cases, a decrease in bacterial bioburden.