The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel

A Geissler, A Chacinska, KN Truscott, N Wiedemann… - Cell, 2002 - cell.com
A Geissler, A Chacinska, KN Truscott, N Wiedemann, K Brandner, A Sickmann, HE Meyer…
Cell, 2002cell.com
Mitochondrial proteins with N-terminal targeting signals are transported across the inner
membrane via the presequence translocase, which consists of membrane-integrated
channel proteins and the matrix Hsp70 import motor. It has not been known how preproteins
are directed to the import channel. We have identified the essential protein Tim50, which
exposes its major domain to the intermembrane space. Tim50 interacts with preproteins in
transit and directs them to the channel protein Tim23. Inactivation of Tim50 strongly inhibits …
Abstract
Mitochondrial proteins with N-terminal targeting signals are transported across the inner membrane via the presequence translocase, which consists of membrane-integrated channel proteins and the matrix Hsp70 import motor. It has not been known how preproteins are directed to the import channel. We have identified the essential protein Tim50, which exposes its major domain to the intermembrane space. Tim50 interacts with preproteins in transit and directs them to the channel protein Tim23. Inactivation of Tim50 strongly inhibits the import of preproteins with a classical matrix-targeting signal, while preproteins carrying an additional inner membrane-sorting signal do not strictly depend on Tim50. Thus, Tim50 is crucial for guiding the precursors of matrix proteins to their insertion site in the inner membrane.
cell.com
以上显示的是最相近的搜索结果。 查看全部搜索结果

Google学术搜索按钮

example.edu/paper.pdf
搜索
获取 PDF 文件
引用
References