The modifier subunit of Drosophila glutamate-cysteine ligase regulates catalytic activity by covalent and noncovalent interactions and influences glutathione …
JA Fraser, P Kansagra, C Kotecki… - Journal of Biological …, 2003 - ASBMB
Glutamate-cysteine ligase (GCL) has a key influence on glutathione homeostasis. It has
been proposed that mammalian GCL is regulated by the redox environment, and we show
here that cysteine residues in the Drosophila melanogaster GCL modifier subunit
(DmGCLM) can form covalent interactions with the catalytic subunit (DmGCLC) and modify
its activity. Candidate components of intersubunit disulfides (Cys 213, Cys 214, and Cys
267) were identified using matrix-assisted laser desorption ionization time-of-flight …
been proposed that mammalian GCL is regulated by the redox environment, and we show
here that cysteine residues in the Drosophila melanogaster GCL modifier subunit
(DmGCLM) can form covalent interactions with the catalytic subunit (DmGCLC) and modify
its activity. Candidate components of intersubunit disulfides (Cys 213, Cys 214, and Cys
267) were identified using matrix-assisted laser desorption ionization time-of-flight …
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