The non-amyloidal component region of α-synuclein is important for α-synuclein transport within axons
EN Anderson, D Hirpa, KH Zheng… - Frontiers in Cellular …, 2020 - frontiersin.org
Proper transport of the Parkinson's disease (PD) protein, α-synuclein (α-syn), is thought to
be crucial for its localization and function at the synapse. Previous work has shown that
defects in long distance transport within narrow caliber axons occur early in PD, but how
such defects contribute to PD is unknown. Here we test the hypothesis that the NAC region
is involved in facilitating proper transport of α-syn within axons via its association with
membranes. Excess α-syn or fPD mutant α-synA53T accumulates within larval axons …
be crucial for its localization and function at the synapse. Previous work has shown that
defects in long distance transport within narrow caliber axons occur early in PD, but how
such defects contribute to PD is unknown. Here we test the hypothesis that the NAC region
is involved in facilitating proper transport of α-syn within axons via its association with
membranes. Excess α-syn or fPD mutant α-synA53T accumulates within larval axons …
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