… E domain is responsible for many functions, mostly ligand induced, notably the AF-2 …
Nuclear receptors may or may not contain a final domain in the C-terminus of the E domain, the F …

… Despite diversity in the size, shape, and charges … the nuclear receptor superfamily share a
common modular domain structure.15, 57 Except for the atypical receptors SHP and DAX, the …

… that the two central residues within the active site Cys-30-Pro-31-His-32-Cys-33 motif are
critical in determining the … Mutations that change these two residues can alter the equilibrium …

… the basic principles of the mode of action of nuclear receptors, this review will focus … the
various factors that are instrumental in modulating the pharmacology of nuclear receptors…

… the analysis of complete genomes? In summary, the study of the evolution of nuclear receptors
… in vivo but also for obtaining insights into the evolution of animal genomes as a whole. …

… The nuclear receptors (NRs) are a family of transcription … The NR family also encodes metabolic
sensors for other cholesterol… Still, a distinct subset of the NRs remains “orphans,” lacking …

… how such chimeric receptors could be used to characterize the ligand requirement … the NR
superfamily: hooking the LBD of a novel receptor candidate to the DBD of either the ER or the …

A unified nomenclature system for the nuclear receptor superfamily — University of Texas
Southwestern Medical Center … For all open access content, the Creative Commons …

… is focused on the functional analysis of nuclear receptors. … the nuclear-localized receptors
TR and RAR led to the … and thyroid (SMRT) receptors and the nuclear receptor co-repressor (…

… The evolutionary acquisition by nuclear receptors of the ability to heterodimerise clearly
increased the diversity of regulatory functions that these factors can mediate. This functional …